Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 287-335-8
CAS number: 85480-55-3
- 1, 2, or 3 normally describes the primary
irritation of the skin which develops from application of the test
substance. However, in the evaluation of a material for its ability to
induce an allergic reaction, reactions obtained in the challenge period
are the most meaningful.
- A grade of 1, 2, or 3 normally is not
suggestive of sensitization, whereas a grade of 4, 5, or 6 usually
denotes an allergic response.
- Allergic responses typically do not
improve markedly at 96 hours and should be of nearly equal intensity on
the original and alternate sites.
- Any grade of 2 or higher necessitates
relocation of a patch.
- Grades of 2 or 3 early in the induction
period usually are indicative of primary irritation, and a reduction in
concentration of the test substance may be warranted.
- A sudden increase in severity of a
response in the latter portion of the induction may be suggestive of
The study was designed to evaluate the
absence of skin sensitization potential of 0.5% monoethanolamine aqueous
solution when applied to human skin in the human repeat insult patch
test (HRIPT). The same panel of volunteers were also exposed to 0.1%
CnAE6S (ammonium neutralized coconut chain length surfactant with an
average ethoxylate value of 6) to evaluate the skin sensitization effect
A total of 119 adult male and females were
employed in the study and only 90 of them completed the study. In
induction phase, subjects were exposed to 0.5 mL of 0.5% aqueous
solution of the test substance under occlusive patches on the dorsal
surface of upper arm for 24 hours on Monday, Wednesday and Friday for 3
subsequent weeks. The test substances (MEA and CnAE6S) were applied in
four different orders to eliminate position and order bias. After 14
days rest period subjects were challenged with two set of patches, one
at original site and other at alternative site (to other arm). The
application sites were scored after removal of every induction patch and
after 48 and 96 hours of removal of challenge patch.
The total score (for both pilot and main
test) for no irritation and mild irritation were 998 and 243,
respectively. No subjects demonstrated moderate, strong or severe
After challenge, 12/90 subjects revealed
faint but distinct erythema (grade 1). The overall level of irritation
for monoethanolamine was very mild after patch application to skin.
Under the test conditions, 0.5% aqueous
solution of monoethanolamine (PZD-75.001a; purity: 97%) did not produce
skin sensitization in human volunteers during the human repeated insult
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again