Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-152-2
CAS number: 78-87-5
Mean analysed concentrations of PDC were 5.0 (0.0), 15.0 (0.0) and 62.5
(2.0) mg/ml (SD in brackets).
Clinical signs (ie decreased movement and muscle tone, increased
lacrimation, decreased extensor reflex and increased salivation) were
present in high dose animals on GD 6 and to a lesser extent on GD 7.
Despite the transitory nature of these changes, they appeared indicative
of an adverse effect in dams from the high dose group. No clinical
effects were seen on other days in the high dose group, or on any day in
the mid- or low dose animals.
Body weights were slightly (3-5%) but significantly lower in high dose
dams throughout the study. Body weight gain was decreased significantly
in high dose dams on GD 6-9, and although comparable to control during
the mid- and latter stages of pregnancy the overall weight increase in
the 125 mg/kg bwt/day group was approx. 30% lower than controls on GD
6-16 (that is, during the dosing period). Food consumption was reduced
approx. 25% on GD 6-9, and water consumption increased by the same
amount on GD 9-12 and 12-15.
There were no significant effects on absolute or relative organ weights,
or on uterine weights or pregnancy parameters (including number of
litters, corpora lutea per dam, implantations per dam, live fetuses per
litter, resorptions, fetal bwt, etc).
A low incidence of malformations was present in all groups, with no
qualitative or quantitative increase in litters from treated dams.
Overall there was no indication that PDC was a teratogen.
Fetal variations were present in both control and treated groups. The
only treatment-related effect was a significant increase in the
incidence of delayed ossification of the bones of the skull among
fetuses from the high dose group. Interestingly, the occurrence of this
observation was most common in high dose litters containing 16 or more
pups. All other parameters were comparable to the controls.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Questo sito web si avvale di cookie affinché possiate usufruire della migliore esperienza sui nostri siti web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again