Registration Dossier

Administrative data

Endpoint:
long-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
OECD SIDS 1,2-DICHLOROPROPANE
Author:
OECD SIDS
Year:
2003
Bibliographic source:
UNEP PUBLICATIONS
Report Date:
2003

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
for method see "Materials and methods"
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name: 1,2-dichloropropane

Sampling and analysis

Analytical monitoring:
yes

Test organisms

Test organisms (species):
Pimephales promelas

Study design

Total exposure duration:
28 d

Results and discussion

Effect concentrations
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
6 - 11 mg/L

Any other information on results incl. tables

Measured exposure concentrations were 0, 6, 11, 25, 51 and 110 mg/l. Embryo hatchability was 96% - 98%, with no treatment-related differences apparent, however the percentage of normal larvae was decreased significantly in the 51 mg/l and 110 mg/l tanks (decreased 33% and 100%, respectively). Body weight at day 28 was reduced significantly in larvae exposed to 11 mg/l and above, while larval survival was significantly decreased at 25 mg/l and above. The authors estimate that the Maximum Acceptable Toxicant Concentration (MATC, defined as a hypothetical toxic threshold falling mid-way between the NOEC and LOEC) for PDC is 59 mg/l.

Applicant's summary and conclusion

Conclusions:
Under the conditions of this ELS test in Fathead minnows, a chronic NOEC of 6 mg/l was obtained for growth and a chronic NOEC of 11 mg/l obtained for survival.