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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
OECD SIDS 1,2-DICHLOROPROPANE
Author:
OECD SIDS
Year:
2003
Bibliographic source:
UNEP PUBLICATIONS
Report Date:
2003

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EPA OPPTS 870.5395 (In Vivo Mammalian Cytogenetics Tests: Erythrocyte Micronucleus Assay)
GLP compliance:
yes
Type of assay:
micronucleus assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name. 1,2-dichloropropane

Test animals

Species:
mouse
Strain:
CD-1
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Duration of treatment / exposure:
48 hr
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 150, 300 or 600 mg/kg bwt/d
Basis:

Results and discussion

Any other information on results incl. tables

All animals survived until the end of the observation period. Incoordination was observed in one mouse from the high-dose group. A uniform drop in body temperature (approx. 2ºC) occurred 2 hrs post-dosing in the high-dose animals. There was no statistically significant increase in the frequencies of MN-PCE in groups treated with PDC when compared to the negative controls. In contrast, a significant increase in the frequency of MN-PCE was recorded in the positive control group. The mean proportion of PCE among bone marrow erythrocytes (200/animal) was unaffected by exposure to the test material while the positive control treatment significantly reduced this value.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
1,2 dichloropropane was negative for the induction of micronuclei in this test system under the experimental conditions used.