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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
OECD SIDS 1,2-DICHLOROPROPANE
Author:
OECD SIDS
Year:
2003
Bibliographic source:
UNEP PUBLICATIONS
Report Date:
2003

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name: 1,2-dichloropropane

Test animals

Species:
rabbit

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Duration of treatment / exposure:
4h
Number of animals:
3 rabbits (2male, 1 female)

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Time point:
other: 4 h
Score:
1
Irritation parameter:
edema score
Basis:
mean
Time point:
24 h
Score:
1
Max. score:
1
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
48 h
Score:
0
Max. score:
0
Reversibility:
other: not applicable
Irritation parameter:
edema score
Basis:
mean
Time point:
72 h
Score:
0
Max. score:
0
Reversibility:
other: not applicable
Irritation parameter:
erythema score
Basis:
mean
Time point:
24 h
Score:
2
Max. score:
2
Reversibility:
not fully reversible within: 8 days
Irritation parameter:
erythema score
Basis:
mean
Time point:
48 h
Score:
> 1 - < 2
Max. score:
2
Reversibility:
not fully reversible within:
Irritation parameter:
erythema score
Basis:
mean
Time point:
72 h
Score:
1
Max. score:
1
Reversibility:
other: reversible after 8 days in 2/3 animals

Any other information on results incl. tables

Individual reactions at 24 hr:

Redness 2, 2, 2

Oedema 1, 1, 1

Individual reactions at 48 hr:

Redness 2, 1, 1

Oedema 0, 0, 0

Individual reactions at 72 hr:

Redness 1, 1, 1

Oedema 0, 0, 0

Individual reactions at 8 d

Redness 1, 0, 0

Oedema 0, 0, 0

Flaking skin at application site in all animals

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Slightly irritating to skin.