Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
OECD SIDS 1,2-DICHLOROPROPANE
Author:
OECD SIDS
Year:
2003
Bibliographic source:
UNEP PUBLICATIONS
Report Date:
2003

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method not available
GLP compliance:
no
Test type:
acute toxic class method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name. 1,2-dichloropropane

Test animals

Species:
rat
Strain:
other: Carforth-Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 200 mg/kg bw

Any other information on results incl. tables

Acute oral LD50 = 1.9 +/- 0.2 ml/kg (mean and SD) This is equivalent to 2200 mg/kg bw, based on a density of 1.155 g/ml [Source: MacKay et al (1993) Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals, Vol III, p479]

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 = 2200 mg/kg bw