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EC number: 204-411-8
CAS number: 120-61-6
Reproductive summary data.
Mean gestation period (days)
Mean Litter Size
Mortality % at birth
Mortality % birth to weaning
Mean Pup wt (g) at weaning
aNumber in parentheses are extremesbStatistically
different from control, p<0.05
Dimethyl terephthalate was administered to groups of 20 male rats in the
diet for 115 days, at doses of 0, 0.25, 0.5 and 1.0%.
The male rats were then mated with twenty virgin females which had also
been fed the dimethterephthalate diet for 6 days prior to mating. Male
rats treated with dimethyl terephthalate showed normal mating behaviour.
All treatment groups had a higher percentage of inseminations than the
control group. Ninety-five to 100% of these inseminations resulted in a
pregnancy with a normal gestation period and litter size. The only
effect seen in pups was a statistically significant reduction in body
weight at weaning compared to the control in the 0.5 and 1.0% dose
groups. The NOAEL for reproductive toxicity can be considered to be 1%
dimethyl terephthalate in the diet, the NOAEL for parental toxicity was
0.5% and the NOAEL for offspring toxicity was 0.25%.
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