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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Two reliable (Klimisch 2/1, guideline- and GLP-compliant) studies address the short-term toxicity of dimethyl terephthalate to freshwater fish.   
In the first study (Anonymous, 1994), zebra fish (Danio rerio) were exposed to high purity DMT, dosed from a saturated aqueous stock solution. The highest achievable, dissolved exposure concentration was 36 mg DMT/L.
Zebra fish (D. rerio) 96 -h LC50 (semi-static): 13 mg DMT/L, 96 -h NOEC: 9.6 mg DMT/L.
These endpoints are mean measured values based on non-specific analyses of organic carbon (OC). Based on evidence of hydrolytic stability for >24 h in other studies, it is assumed that DMT remained substantially intact under the semi-static media renewal regime employed in this study.
In the second study (Government of Japan, Ministry of the Environment, 2002a) himedaka (Oryzias latipes) were exposed to high purity DMT, dosed from a stock solution prepared with THF. No toxicity was observed under these test conditions:
Himedaka (O. latipes) 96 -h LC50 (semi-static): >5.37 mg DMT/L, 96 -h NOEC: 5.37 mg DMT/L.
These endpoints are mean measured values and represent the maximum limit concentration achievable under the test conditions with the dosing regime employed.

Key value for chemical safety assessment

LC50 for freshwater fish:
13 mg/L

Additional information