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EC number: 204-411-8
CAS number: 120-61-6
In a study on dimethyl terephthalate using the Kodak Drop-on Method, a
group of ten guinea pigs was treated with multiple topical applications
of 0.5 mL of a 1.0% solution of the test substance in
acetone + dioxane + guinea pig fat (7:2:1). After a three-week rest
period, the animals were treated again with the solution on one shoulder
and one week later, on the other shoulder . The final observations were
compared to the initial observations to determine potential
sensitization by the test material. A group of five control guinea pigs
was treated with only the solvent mixture. Twenty-four and forty-eight
hours after challenge, the reactions in the control and test groups were
similar. Based on the results of this study using the Kodak Drop-on
Method, it was determined that dimethyl terephthalate was a not a dermal
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