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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published study.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute intraperitoneal toxicity (rat)
GLP compliance:
no
Remarks:
predates GLP
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
The material is made by Tennessee Eastman Company, catalogue No. 6580. It was described as a white crystalline material.

Test animals

Species:
rat
Strain:
Long-Evans
Sex:
male
Details on test animals and environmental conditions:
The animals were Long-Evans hooded rats, chosen because of the low mortality due to spontaneous lung disorders.

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
corn oil
Details on exposure:
Doses of 3000, 3900, 5020 and 6590 mg/kg bw dimethyl terephthalate (20% in corn oil) were administered intraperitoneally to male rats (3-6 per group).
Doses:
Doses of 3000, 3900, 5020 and 6590 mg/kg bw.
No. of animals per sex per dose:
3-6 male rats per group.
Control animals:
yes
Details on study design:
Doses of 3000, 3900, 5020 and 6590 mg/kg bw dimethyl terephthalate (20% in corn oil) were administered intraperitoneally to male rats (3-6 per group) to determine the LD50. All groups were observed for signs of toxicity for 14 days. At the end of the test, the survivors were autopsied and examined for gross and micropathology.
Statistics:
No information available.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
3 900 mg/kg bw
Based on:
test mat.
Mortality:
All deaths occurred within 48 hours of injection.
Clinical signs:
Symptoms were slight to moderate weakness at all dose levels, and slight tremors and some ataxia at the two highest doses (5020 and 6590 mg/kg).
Body weight:
Not measured.
Gross pathology:
Except for peritoneal irritation with foreign body reaction on the surface of the abdominal viscera, no morphologic evidence of gross or microscopic abnormalities was seen in the organ systems of the DMT treated animals.
Other findings:
No other findings.

Any other information on results incl. tables

No further remarks.

Applicant's summary and conclusion

Conclusions:
The acute intraperitoneal LD50 of dimethyl terephthalate in rats was found to be 3900 mg/kg bw under the conditions of this study.
Executive summary:

The acute intraperitoneal toxicity of DMT was investigated in the rat.

Dose levels of 3000, 3900, 5020 and 6590 mg/kg bw dimethyl terephthalate (20% in corn oil) were administered intraperitoneally to male Long-Evans rats (3-6 per group). All deaths occurred within 48 hours of injection. Symptoms were slight to moderate weakness at all dose levels, and slight tremors and some ataxia at the two highest doses (5020 and 6590 mg/kg bw). Except for peritoneal irritation with foreign body reaction on the surface of the abdominal viscera, no morphologic evidence of gross or microscopic abnormalities was seen in the organ systems of the DMT treated animals. The acute intraperitoneal LD50 of dimethyl terephthalate in rats was found to be 3900 mg/kg bw under the conditions of this study.