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EC number: 204-411-8
CAS number: 120-61-6
Dimethyl terephthalic acid was not carcinogenic to rats and mice fed diets containing 2500 or 5000 ppm for 2 years.
There was no definitive evidence that dimethyl terephthalate is
carcinogenic to rats and mice, when fed in the diet for 2 years.
Therefore the classification according to Regulation (EC) No. 1272/2008
is not required.
The carcinogenicity of DMT has been investigated in two high qualtiy
studies in F344 rats and B6C3F1 mice (National Cancer Institute, 1979).
Groups of 50 animals per species per sex were administered dimethyl
terephthalate at doses of 2500 or 5000 ppm for 103 weeks, then observed
for an additional 2 weeks. Matched controls consisted of 50 untreated
animals per species per sex. No clinical behaviour was observed which
was related to the treatment. Survival at the end of the study was not
affected by the test material. A variety of tumors were observed in both
control and dosed rats. However, there was no difference in the type or
number of lesions in the dosed or control group. In mice of each sex, no
tumors occurred at incidences that clearly were related to
administration of the test chemical. The occurrence of lung tumours in
male mice was considered equivocal, based on an unusually low occurrence
of this type of tumour in control mice. It was concluded that under the
conditions of the study, dimethyl terephthalate was not carcinogenic for
F344 rats and B6C3F1 mice.
Dose levels are calculated using default factors to be equivalent to 125
and 250 mg/kg bw/d (rat); 375 and 750 mg/kg bw/d in the mouse.
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