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EC number: 204-411-8
CAS number: 120-61-6
The result of this study contrasts with the positive findinings reported
by Goncharova et al (1988), in which dimethyl terephthalate was
reported to induce micronuclei in the bone marrow cells of male mice
following single intraperitoneal injections of doses ranging from 0.2 to
1.0 mmol/kg (approximately 33 to 166 mg/kg bw). It is notable that DMSO
was used as the solvent in that study, which may have contributed to the
difference in results between these two studies.
Dimethyl terephthalate was tested in the mouse bone marrow micronucleus
assay, for the US National Toxicology Program. The test substance was
administered in three daily exposures by intraperitoneal injection, at
doses of 0, 438, 875 and 1750 mg/kg bw. Bone marrow samples were
obtained 24 h following the final exposure. DMT did not induce
micronuclei in the bone marrow of male mice following three
intraperitoneal injections at up to and including a dose of 1750 mg/kg.
Administration of DMT did not result in any mortality.
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