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Short-term toxicity to aquatic invertebrates

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Two reliable (Klimisch 1, guideline- and GLP-compliant) studies address the short-term toxicity of dimethyl terephthalate to freshwater invertebrates. 
In the first study (Salinas, 2010a) Daphnia were exposed to high purity DMT dissolved at concentrations up to 23.5 mg/L, dosed from a saturated solution prepared with Elendt M4 medium. Slight toxicity (15% immobilisation after 48 h) was observed at the highest treatment:
D. magna 48 h EC50 (static): >23.5 mg DMT/L, 48 h NOEC: 10.8 mg DMT/L.
These endpoints are based on "theoretical" exposure concentrations: the measured initial concentration in the highest treatment and calculated lower concentrations derived by serial dilution.
In the second study (Government of Japan, Ministry of the Environment, 2002b), Daphnia magna were exposed to high purity DMT, dosed from a stock solution prepared with THF. No toxicity was observed under these test conditions:
D. magna 48 -h EC50 (semi-static): >6.50 mg DMT/L, 48 -h NOEC: 6.50 mg DMT/L.
These endpoints are nominal and represent the maximum limit concentration achievable by the dosing regime employed under the test conditions.

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