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EC number: 700-597-4
CAS number: 1215841-86-3
In vitro studies:
Three in vitro genetic toxicity tests were performed to examine
the potential of the substance
to induce mutations.
In a bacterial mutation test using the Salmonella typhimurium
strains TA 1535, TA 1537, TA 98, TA 100 and TA 102, with and without the
addition of a metabolising system according to OECD method 471 tested up
to a concentration of 5000 µg/plate, the substance caused no mutagenic
effect neither in the plate incorporation test nor in the preincubation
test each carried out without and with metabolic activation.
Furthermore an in vitro micronucleus test was conducted. Under the
present test conditions, tested up to a concentration of 5000 µg /mL
medium in the absence and in the presence of metabolic activation the
substance revealed no indications of mutagenic properties in the in
vitro micronucleus test.
The substance was tested for mutagenic potential in a gene
mutation assay in cultured mammalian cells (HPRT test) both in the
presence and absence of metabolic activation. Under the present test
conditions, tested up to concentrations of 5000 µg/mL in the experiments
without and with metabolic activation the substance was negative in the
HPRT-V79 mammalian cell mutagenicity test
According to the criteria of EC Directive 67/548/EEC and EC
Regulation 1272/2008 and subsequent regulations on classification,
labelling and packaging of substances and mixtures and based on the
results of the studies
is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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