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EC number: 700-597-4
CAS number: 1215841-86-3
The test substance
was examined for its potential to induce gene mutations in the plate
incorporation test and the pre-incubation test using the Salmonella
typhimurium strains TA 1535, TA 1537, TA 98, TA 100 and TA 102, with and
without the addition of a metabolising system (Arochlor 1254 induced rat
liver S9 mix)
examined in two preliminary cytotoxicity tests (plate incorporation test
without and with metabolic activation) in test strain TA 100. Ten
concentrations ranging from 0.316 to 5000 µg/plate were tested. No signs
of cytotoxicity were noted up to the top concentration of 5000 µg/plate.
Hence, 5000 µg of the test item/plate was chosen as top
concentration for the main study in the plate incorporation test and in
the preincubation test, respectively.
Six concentrations ranging from 31.6 to 5000 µg trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide/plate
were employed in two independent experiments each carried out without
and with metabolic activation.
No signs of cytotoxicity were noted in the plate incorporation
test or in the preincubation test, each carried out without and with
metabolic activation, up to the top concentration of 5000 µg/plate in
all test strains.
No mutagenic effect (no increase in revertant colony numbers as
compared with control counts) was observed for the test item, tested up
5000 µg/plate,in any of the 5 test strains in two independent
experiments without and with metabolic activation, respectively (plate
incorporation and preincubation test).
under the present test conditions trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide
tested up to a concentration of 5000 µg/plate, caused no mutagenic
effect in theSalmonella typhimuriumstrains TA 98, TA 100, TA 102,
TA 1535 and TA 1537 neither in the plate incorporation test nor in the
preincubation test each carried out without and with metabolic
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