Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-597-4
CAS number: 1215841-86-3
no further remarks
The aim of the present experiment was to obtain information on the
acute toxicity and LC50, following a single 4-hour inhalation exposure
in an acute inhalation study in rats.
3 male and 3 female rats were exposed to trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide
at a concentration of 5.07±0.01 mg test substance/L air for 4 hours by
inhalation using a dynamic nose-only exposure chamber. The aerosol was
generated with the aid of a dry, rotating brush dust generator. In the
inhalation chamber, close to the animals' noses, the generated aerosol
particulates had a mass median aerodynamic diameter (MMAD) of 3.615 µm
as determined with a cascade impactor. The Geometric Standard Deviation
(GSD) of the MMAD was calculated as 2.85.
Under the present test conditions, a 4-hour inhalation LC50 of trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide
revealed slight ataxia and slight dyspnoea immediately until 60 minutes
or 3 hours after end of exposure. No animal died prematurely. No
pathological findings were noted at necropsy. One of the 3 female
animals appeared to be reduced in body weight gain.
Therefore LC50 exceeding 5.07 mg/L air for both sexes combined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Tällä verkkosivustolla käytetään evästeitä parhaan mahdollisen käyttäjäkokemuksen varmistamiseksi.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again