Registration Dossier

Administrative data

Description of key information

 The acute toxicity of trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide was examined. After oral application the LD50 for rats was found to be > 2000 mg/kg bw. The acute inhalation LC50 for rats was found to be > 5.07 mg/L .

Key value for chemical safety assessment

Additional information

Studies in Animals:

Oral

After oral application the LD50for rats was found to be > 2000 mg/kg bw in a test performed according to OECD Guideline 423. No signs of toxicity were observed. No animal died prematurely.

Inhalation:

After exposition via inhalation (dust) the LC50 for rats was found to be > 5.07 mg/L bw in a test performed according to OECD Guideline 403. The animals showed slight ataxia and slight dyspnoea. No animal died prematurely. No pathological findings were noted at necropsy. One of the 3 female animals appeared to be reduced in body weight gain.

Justification for classification or non-classification

According to the criteria of EC Directive 67/548/EEC and EC Regulation 1272/2008 and subsequent regulations on classification, labelling and packaging of substances and mixtures and based on the results of the studies trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide is not classified.