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EC number: 200-929-3
CAS number: 76-05-1
No clinical signs and no mortality were
observed during the study. The body weight gain of the treated animals
was similar to that of the control animals. No cutaneaous reactions and
no increase in ear thickness were observed at any of the test item
The quantity of cells obtained in each group
was satisfactory and the cellularity correlated with incorporation of
3H-TdR. The cell viability was higher than 80% in each group.
In a dermal
sensitisation study performed according to the OECD guideline No.429
(April 2002) and in compliance with the GLP, ethyl trifluoroacetate
(purity 99.94%) in acetone/olive oil was administered to CBA/J mice. The
Lymph node proliferative responses were measured as described by Kimber
and Dearman (1991). Ethyl
Trifluoroacetate (CAS 383-63-1) was identified as a structural analogue
of TFA and considred as relevant to assess the sensitising potential of
TFA. In fact, the acid function substitution by the ethyl group
represents the only difference between both substance structures (TFA
and ethyl trifluoroacetate), while the ethyl group is not known to
induce sensitisation in the literature.
positive control used was HCA (α-hexylcinnamaldehyde)
which presented a Stimulation index of 5.24.Therefore, the positive
control gave acceptable positive results and the study can be considered
signs and no mortality were observed during the study. Furthermore, no
irritation of the skin was noted following the application of the test
item. The LLNA gave negative results, as the SI is lower than 1 in the
animals treated whatever the concentration of the test item.
test conditions, the test item ethyl trifluoroacetate is not a dermal
sensitizer in the murine Local Lymph Node Assay.
is considered as acceptable as it satisfies the main criteria of OECD
guideline No. 429.
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