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EC number: 200-929-3
CAS number: 76-05-1
In aqueous solution, the pH of the substance is naturally low and
for testing under realistic environmentally conditions either the sodium
salt (NaTFA) or pH adjustment were required.
inherent biodegradability test was conducted in compliance with the
methods described in OECD test Guideline 302 A and EEC Directive 87/302
with some minors deviations. Because of the great potential for
promoting biodegradation under aerobic conditions, the semi-continuous
activated sludge (SCAS) test was chosen and Trifluoroacetic acid, sodium
salt was exposed to relatively high concentrations of microorganisms
maintained by daily addition of primary settled sewage. The test was
conducted for a period of 127 days and the non-purgeable organic carbon
(NPOC) was determined in the effluent. . The test compound caused no
reduction of the biodegradation of the NPOC present in primary settled
waste water, therefore Trifluoroacetic acid, sodium salt is considered
to be non-inhibitory to the activated sludge. Trifluoroacetic acid,
sodium salt was removed approximately 20% from the wastewater in the
SCAS test. Biodegradation of Trifluoroacetic acid has to lead to the
formation of fluoride that was not detected in the effluent of SCAS
units. This result also demonstrates that Trifluoroacetic acid, sodium
salt is not biodegraded.
Another test, not performed according to standardised guideline but with
an acceptable scientific method, was conducted in order to assess the
cometabolic transformation of Trifluoroacetic acid, sodium salt, by
microorganisms present in various inocula for a period of 84 days. The
biodegradation of this compound in the presence of various co-substrates
(acetic acid, peptone, yeast extract and vitamin B12) was determined by
measuring the formation of fluoride. The addition of various
co-substrates did not initiate a cometabolic transformation of
Trifluoroacetic acid, sodium salt. which was not biodegraded in the
Two other non standardized tests investigated further the
biodegradability of TFA. Even if the methodology was scientifically
acceptable, the report was not sufficiently documented to assess the
reliability of the results. The first study evaluated the ability of
aerobic bacteria, previously shown to have a broad range of degradative
capabilities, to degrade trifluoroacetic acid (TFA). Nine different
bacterial strains were tested in bottle assays for their dehalogenation
analysis, using 14C TFA to test for production of 14CO2. This study
failed to show degradation of TFA by all strains. The second test was
conducted to assess its biodegradability in an engineered anaerobic
reactor in a long-term (90 weeks) study . Trifluoroacetic acid was found
to be cometabolically degradable in an anaerobic environment.
In conclusion, trifluoroacetic acid is not readily biodegradated in
water and no biodegradation and cometabolic transformation by any of the
microorganisms tested was observed under aerobic conditions. A not
assignable study show that cometabolic degradation in anaerobic
conditions can happen.
Biodegradation testing in soil and sediment was not conducted for TFA
(according to column 2 of Annex IX of REACH), because direct and
indirect exposure of soil and sediment is unlikely based on its low
adsorption potential (log Kow = 0.79 and 6.8 < log Koc< 15 L/kg at 25°C).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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