Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-929-3
CAS number: 76-05-1
Several studies on plants are available for trifluoroacetic acid. Two
keys studies were performed according to OECD 208 guideline on three
different species. The lowest EC50 was measured for shoot growth of mung
bean at 4.7 mg/kg DW and the NOEC was determined at 0.83 mg/kg DW for
the three species. Nine other studies on hydroponic and atmospheric
exposures of several plants species and on bioaccumulation of TFA
supported these results. According to column 2 of REACH Annex IX and X,
no further studies need to be conducted on terrestrial organisms for
trifluoroacetic acid because direct and indirect exposure of soil is
unlikely based on its low potential for adsorption to soil (log Kow =
0.79 and Kd= 0.94 L/kg at 25°C) and the soild compartment is included in
the Chemical Safety Assessment.
No relevant data are available on birds or mammals however, it is
assumed that there is no need to conduct a secondary poisoning
assessment for trifluoroacetic acid based on low exposure and low
toxicity considerations. Indeed, according to the triggering criteria
described in R.184.108.40.206, the substance has a low potential for
bioaccumulation (Log Kow < 3, not highly adsorptive, Log Koc= 0.94 l/kg)
and low levels of incorporation have been measured in several aquatic
and terrestrial organisms showing BCF values < 100. Moreover, acute
toxicity results on mammals (rats) exposed via the oral route from day
10 to day 20 of gestation show only slight but transient changes without
being predictive of any developmental effect.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again