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EC number: 200-929-3
CAS number: 76-05-1
This endpoint is covered by four studies. The key study, an activated sludge respiration inhibition test, shows that the NOEC, EC10 and EC50 after 3 hours were clearly higher than 832 mg TFA/L. The other studies on the mode of action support this result suggesting that TFA presented no acute or chronic effect on acetate metabolism and methanogenic systems.
This endpoint is covered by four studies. A key study, performed
according to standard guidelines and GLP, which
evaluated the influence of Sodium trifluoroacetate on the activated
sludge respiration rate under defined conditions and three supporting
studies, not performed according to international guidelines and
without GLP statement, which evaluated the effects of trifluoroacetic
acid on freshwater microbial communities, on microbial methanogenesis,
and on acetate metabolism by stream microbial communities.
In the key study, the 3 hours EC10, EC20 and EC50 could not be
quantified because up to the highest nominal test concentration (1000
mg NaTFA/L, corresponding to 832 mg TFA/L) less than 10% inhibition
was noted. Nevertheless, the 3-hour EC20 and EC50 are clearly higher
than 832 mg TFA/L under the present test conditions. The NOEC/EC10 may
be established above 832 mg TFA/L.
Moreover, three supporting studies indicated no acute/chronic effects
of TFA on acetate metabolism (TFA did not reduce methane formation
from acetate) and no effect of TFA on tested methanogenic systems (TFA
is inert in these methanogenic systems and there is no evident
toxicity to either the methanogenic or fermentative population).
However, a potential to be actively incorporated by microorganisms
have been found.
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