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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only secondary literature
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1964
Report Date:
1964

Materials and methods

GLP compliance:
no
Remarks:
study performed before GLP establishment

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Data from handbook, no specific composition is available.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
no data
No. of animals per sex per dose:
90 rats
Statistics:
Method of G.N. Pershin and Lichtfield and Wilcoxon as modified by Rot.

Results and discussion

Preliminary study:
no data
Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD100
Effect level:
1 000 mg/kg bw
Sex:
not specified
Dose descriptor:
LD0
Effect level:
250 mg/kg bw
Sex:
not specified
Dose descriptor:
other: LD10
Effect level:
500 mg/kg bw
Clinical signs:
breathing disturbance, motor activity intensified immediately after the administration
Gross pathology:
haemorrhaging and necrosis in the mucous membranes of the stomach, dystrophic changes in the liver, kidneys and brain

Any other information on results incl. tables

No other information

Applicant's summary and conclusion

Executive summary:

The fluoroacids were administered intragastrically in a single dose in aqueous solution to 90 rats followed by a 14-day observation period.

LD100 = 1000 mg/kg bw

LD10 = 500 mg/kg bw

LD0 = 250 mg/kg

In the clinical picture breathing disturbances similar to those that occur in acute inhalation poisoning are observed. In individual animals the motor activity is intensified immediately after administration of the substance, though more often the animals display less movement and motor activity. Varying degrees haemorrhaging and necrosis in the mucous membranes of the stomach, dystrophic changes in the liver, kidneys and brain were detected in macro and micro-investigations of organ of dead rats.

When the neutralised acids in the form of their salt is administered in a single dose into the stomach, the investigated product were found to be practically non-toxic (experiments carried out by Ye. Ya. Golubovich). A dose of 7000 mg/kg bw was not lethal for the animals, and furthermore no signs of damage to the tissues and organs were detected. It shows that the effects seen with the acid must be only applied to the extrem pH of the substance.