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EC number: 200-929-3
CAS number: 76-05-1
Skin and eye irritation/corrosion: Corrosive
considered as a measure of the potential for inducing harmful effects
due to the intensity of alkalinity or acidity (as TFA). However, in
addition to the single parameter pH, the quantity of alkali or acid also
plays a role. The capacity of a substance to maintain its pH (its buffer
capacity) is important in determining biological properties. pH alone
does not determine the total acid alkali in a solution. Young et al.
(1988; see attached document) demonstrated that the pH-acid/alkali
reserve method predicts the classification for irritation and
method generally gives results similar to those obtained from animal
test data (Young et al, 1988).
The pH of a
trifluoroacetic acid aqueous solution at 10% (w/w) is 0.45 and the
measure of the alkali reserve is 35 (as g NaOH/g substance). Following
the pH-acid/alkali reserve method, the classification as corrosive is
predicted for trifluoroacetic acid.
accordance with column 2 of REACH Annex VIII, the in vivo skin
irritation study (required in section 8.1.1) and the in vivo eye
irritation study (required in section 8.2.1) do not need to be conducted
as the substance is a strong acid (pH = 0.45; alkali reserve 35g
NaOH/100 g substance, see §4.20).
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Trifluoroacetic acid is classified according
to Annex VI of Regulation (EC) No 1272/2008 of the European Parliament
and of the Council of 16 December 2008: Trifluoroacetic acid is reported
under the Index No 607-091-00-1 and is classified as Skin Corrosion
Category 1A (H314, Causes severe skin burns and eye damage). A
skin corrosive substance is considered to also cause serious eye damage
which is indicated in the hazard statement for skin corrosion (H314:
Causes severe skin burns and eye damage). Thus, in this case both
classifications (Skin Corr. 1 H314 and Eye Dam. 1 H318) are required,
and therefore Eye Dam.1 H318 is added although not reported in the
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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