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Toxicity to birds

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Annex X states that this study needs to be considered taking into account the mammalian dataset (column 2).
Exposure to birds is not expected . Toxicity data in rats (REACH section 7.2) and dogs (REACH section 7.11) show no overt toxicity by the oral route. Oral PMDI to rats showed the LD50 to be in excess of 10,000 mg/kg body weight. Ingested PMDI forms mainly inert polyureas. There is no reason to suppose that PMDI will show significant oral toxicity to birds. Therefore no tests are deemed necessary.

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