Registration Dossier

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

MDI is virtually unavailable in aqueous solution, and in consequence no bioaccumulation of the substance is expected. The bioconcentration of 4,4’-MDI has been evaluated in this study, using flow-through exposures of 0.8 and 0.08 ug/L MDI. Whereas the analytics (liquid scintillation counting) for this study are suspect due to the expected reactivity of MDI in water and fish tissues, steady state bioconcentration factors (BCFss) of 92 and 200 are reported for these respective MDI exposure concentrations. Using a similar test procedure with (Cyprinius carpio), no measureable bioconcentration of the 4,4'-MDA substance, present at only low concentrations from reaction of MDI with water, was observed. Based on the exposure concentration (0.2 and 0.02 mg/L) and analytical detection limits for water and fish tissues, BCF values of 3-14 and <3-15 (respectively) were reported for these MDA exposures. (EU Risk Assessment Report 4,4’-methylenedianiline).

Key value for chemical safety assessment

Additional information