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PNEC aqua (freshwater)

Two short-term aquatic toxicity studies are available for fish for polymeric MDI (CAS 9016-87-9). In a study with Oryzias latipes (Sumitomo Bayer, 1982) no acute toxicity was observed after 96h exposure to 3000 mg/l (semi-static). A protocol similar to OECD 203 was followed. A test with Danio rerio gave also no mortality at 1000 mg/L (static, OECD 203) (Caspers, 1986). No long-term toxicity study in fish is available.

One short-term study with Daphnia magna is available for polymeric MDI (CAS 9016-87-9). The 24h -EC50 is >1000 mg/l in an OECD 202 test (Caspers et al., 1986). One long-term study with Daphnia magna is available for polymeric MDI (CAS 9016-87-9). The 21d -NOEC50 is >10 mg/l in an OECD 211 test (Caspers et al., 1986).

One freshwater study with the green alga Scenedesmus subspicatus is available for polymeric MDI (CAS 9016-87-9). The 3-d EC50 and 3-d NOEC is 1640 mg/l based on growth rate and nominal concentrations. The test was conducted under static conditions and according to OECD 201 (Blom and Oldersma, 1994).

One OECD 209 Activated Sludge, Respiration Inhibition Test is available for polymeric MDI (CAS 9016-87-9). Based on the respiration rate using activated sludge, the 3-h EC50 is found to be >100 mg/l (Caspers et al. 1986).

These value may be considered for the derivation of a PNEC aqua and a PNEC stp.

Based on the justification in the category approach, it is assumed that all MDI analogues included in the category have similar toxicity effect concentrations.

All aquatic toxicity studies have been conducted in freshwater. However, the hydrolytic behaviour of PMDI in freshwater and seawater is very similar (Yakabe et al, 1994). Therefore, the toxicity of PMDI and its hydrolytic degradation products to both freshwater and the corresponding marine water organisms is expected to be similar.

A PNECaqua (freshwater) of >1mg/l may be derived from the acute toxicity test results and an assessment factor of 1000.

PNECaqua (marine water)

The hydrolytic behaviour of PMDI in freshwater and seawater is very similar (Yakabe et al, 1994). Furthermore the toxicity of PMDI and its hydrolytic degradation products to both freshwater and the corresponding marine water organisms is expected to be similar. Therefore the PNECaqua (marine water) is considered to be the same as the PNECaqua (freshwater).