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EC number: 221-066-9
CAS number: 2996-92-1
Oral (OECD TG 425): LD50: rat: 1049 mg/kg bw (female).
No measured acute dermal toxicity data are available for the registered
substance, trimethoxyphenylsilane, however reliable study are available
for the structural analogue substance triethoxyphenylsilane (CAS:
780-69-8, MW ratio: source/target = 0.82).
Dermal (similar to OECD TG 402): LD50: rabbit: 3014 mg/kg (dose given in
ml/kg, converted using a specific density of 0.99 g/ml)
MW corrected LD50 = 2471 mg/kg bw.
Inhalation: There are no acute inhalation data available.
study is available from the structural analogue triethoxy(phenyl)silane
CAS 780 -69 -8. The LD50 for triethoxy(phenyl)silane was estimated to be
greater than 2000 mg/kg bw from this study. Thus the same is concluded
for trimethoxyphenylsilane. As explained in the justification for type
of information, the differences in molecular structure between the
target and the source are unlikely to lead to differences in the dermal
LD50 that are higher than the typical experimental error of the test
Studies were chosen as key when the
available study was of relevance and of sufficient quality for
classification, labelling and for risk assessment.
The key acute oral toxicity study which was
conducted in compliance with GLP and according to OECD TG 425, reports
an LD50 value of 1049 mg/kg bw (based on an
assumed sigma of 0.5 as reported in the study) for female rats after
single oral administration with the registered substance. All 4 animals
dosed with 2000 mg/kg bw died spontaneously or had to be killed in
extremis due to the clinical signs observed, including an excessive body
weight loss in the three sacrificed animals, while no mortality occurred
in animals dosed with 500 mg/kg bw. At 2000 mg/kg bw the following
observations were seen: ruffled fur, slight sedation, light red
congested lungs, black brown stomach distended with gas, tan
discoloration of kidneys and spleen reduced in size (Harlan Laboratories
No measured acute dermal toxicity data
are available for the registered substance, trimethoxyphenylsilane,
however data are available for the structural analogue substance
triethoxyphenylsilane (CAS: 780-69-8). Since both substances hydrolyse
in contact with water to generate the common silanol hydrolysis product,
phenylsilanetriol, it is considered that read-across between the
substances is appropriate. The molecular weight difference between
target and source is 198.29//240.37 = 0.82.
The key acute dermal toxicity study
was conducted using a protocol that was similar to OECD TG 402, but not
to GLP. The LD50value of 3014 mg/kg bw (dose given in ml/kg,
converted using a specific density of 0.99 g/ml) was identified for the
structural analogue substance triethoxyphenylsilane (Mellon Institute,
1972). The LD50 for the target chemical is MW corrected to be
2471 mg/kg bw.
There are no acute inhalation data
on the available acute oral toxicity study, trimethoxyphenylsilane is
proposed to be classified as R22 ‘’Harmful if swallowed’’ according to
the criteria of EU Directive 67/548/EEC, and Acute Toxic 4 (oral) under
Regulation (EC) 1272/2008. The available data on acute dermal toxicity
of the structural analogue substance, triethoxyphenylsilane
(CAS: 780-69-8), do
not meet the criteria for classification according to Regulation
1272/2008 or EU Directive 67/548/EEC, and are therefore conclusive but
not sufficient for classification of the registered substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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