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EC number: 221-066-9
CAS number: 2996-92-1
Table 1. Test results
*Relative to solvent control. A negative (-) value indicates that growth
was higher than in the solvent control.
Table 1. Results of analysis of test media
Nominal concentration (mg/L)
Measured concentration at 0 hours (mg/L)
Measured concentration at 0 hours as percentage of nominal
Measured concentration at 24 hours (mg/L)
Measured concentration at 24 hours as percentage of nominal
0 (Solvent control)
of the additional sample without algae present to determine biological
Table 2. Test results
Mean growth rate 0-72 h (/day)
Inhibition of growth rate (%)*
Mean total biomass as area under the growth curve ( 10E4 cell days/mL)
Inhibition of biomass (%)*
Mean yield (10E4 cells/mL)
Inhibition of yield (%)*
to solvent control. A negative value indicates that the value of the
parameter was higher than for the solvent control.
ErC50 (72 h) > 100 mg/L (nominal, P. subcapitata, OECD 201)
NOErC (72 h) ≥
100 mg/L (nominal, P. subcapitata, OECD 201)
It is likely that the test organisms were predominantly exposed to the
hydrolysis products of the test substance.
One experimental study for the toxicity of trimethoxyphenylsilane
to aquatic algae is available, in which an EC50 (72 h) value of > 0.2
mg/L and NOEC (72 h) of ≥ 0.2 mg/L were determined for its effects on
the growth rate of Pseudokirchnerella subcapitata (OECD Guideline
201 Alga, Growth Inhibition Test, Springborn Smithers 2008). The same
results were obtained for biomass and yield endpoints.
Analysis of the test media showed that measured concentrations of
the parent substance declined to below the Limit of Quantification (LOQ)
of the analytical method in all treatments within 24 hours of the start
of the test.
The maximum, nominal concentration tested (0.2 mg/L) was slightly
above the functional solubility of trimethoxyphenylsilane (parent form)
in algal medium, which had been determined in a preliminary solubility
trial and ranged from 0.021 - 0.033 mg/L. However, the highest tested
concentration is also well below the predicted solubility of the
substance (1700 mg/L). Therefore, it was deemed suitable to read across
from the structurally analogous substance, trichloro(phenyl)silane (98
-13 -5) as both substances hydrolyse rapidly to form phenylsilanetriol.
In the read-across source study, no effects for either growth rate
or biomass were observed at the highest test concentration of 100 mg/L
(OECD Guideline 201 Alga, Growth Inhibition Test, Springborn Smithers,
2009). The substance is subject to rapid hydrolysis and it is therefore
likely that the test organisms were primarily exposed to hydrolysis
products retained in the test media.
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