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EC number: 221-066-9
CAS number: 2996-92-1
There were no effects on mortality in the control or treated media.
Table 1. Results of analysis of test media
Nominal concentration (mg/L)
Mean measured concentration (mg/L)
Mean measured concentration as percentage of nominal
0 (Solvent control)
*The limit of quantification (LOQ) of the analytical method was 0.0046
Table 2. Test results
Mean percentage mortality after 96 hours
LC50 (96 h) > 100 mg/L (nominal, O. mykiss, OECD 203)
It is likely that the test organisms were predominantly exposed to the
hydrolysis products of the test substance.
One experimental study for the short-term
toxicity of trimethoxyphenylsilane to fish is available, in which an
LC50 (96 h) value of > 0.20 mg/L and a NOEC (96 h) of ≥0.20 mg/L were
determined for the mortality of Oncorhynchus mykiss (OECD
Guideline 203 Fish Acute Toxicity Test, Springborn Smithers 2008).
The results are expressed relative to the
nominal test substance concentration. The corresponding mean measured
concentration of the substance in the treated test medium over the
course of the test was 0.074 mg/l.
The maximum, nominal concentration tested
(0.2 mg/l) was slightly above the functional solubility of the test
substance trimethoxyphenylsilane (parent form) in the fish test medium
(well water), which had been determined in a preliminary solubility
trial and ranged from 0.043 - 0.13 mg/L. However, the highest tested
concentration is also well below the predicted solubility of the
substance (1700 mg/L). Therefore, it was considered appropriate to read
across from the structurally analogous substance, trichlorophenylsilane
(98-13-5), as both substances hydrolyse rapidly to phenylsilanetriol.
In the read-across source study, a
limit test was conducted at a test concentration of 100 mg/l (OECD
Guideline 203 Fish Acute Toxicity Test, Springborn Smithers 2009). No
effects were observed at this concentration to Oncorhynchus mykiss.
As the substance is subject to rapid hydrolysis, it is therefore likely
that the test organisms were primarily exposed to hydrolysis products
retained in the test media.
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