Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-066-9
CAS number: 2996-92-1
The half lives determined with the method used here, are not very
accurate for the very short half lives and generally tend rather to
higher values than to be too short. These limitations were considered
acceptable, because the main goal of the study was to find out whether
the 4 hours half life threshold of the WGK classification can be met or
DT50 = 0.4 h at 25 °C and pH 7 (OECD 111)
A reliable study according to OECD 111 is available for the
substance trimethoxyphenylsilane. This substance has a half-life of 0.4
hours at pH 7 and 25°C. Additional information about this endpoint could
be gathered through QSAR calculation. A half-life of approximately 0.1,
0.6 and 0.1 hours for the hydrolysis of the substance at pH 4, 7, 9
repsectively was obtained using an appropriate calculation method. The
result is considered to be reliable and together with a screening method
based on H-NMR which shows a hydrolysis within minutes and supports the
fast hydrolysis result from the OECD 111 test.
The half-life of a substance at pH 2 is calculated based on:
t1/2(pH 2) = t1/2(pH 4) / 100
Reaction rate increases with temperature therefore hydrolysis will
be faster at physiologically relevant temperatures compared to standard
laboratory conditions. Under ideal conditions, hydrolysis rate can be
recalculated according to the equation:
DT50(XºC) = DT50(T) x e(0.08.(T-X))
Where T = temperature for which data are available and X = target
Thus, for trimethoxyphenylsilane the hydrolysis
half-life at 37.5 ºC and pH 2 (relevant for conditions in the stomach
following oral exposure) and pH 7 (conditions relevant for lungs) is
approximately 1 second and 9 minutes repsectively and it is not
appropriate to apply any further correction for temperature to the limit
The initial hydrolysis products are phenylsilanetriol and methanol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Tällä verkkosivustolla käytetään evästeitä parhaan mahdollisen käyttäjäkokemuksen varmistamiseksi.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again