Registration Dossier
Registration Dossier
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EC number: 210-323-0 | CAS number: 612-83-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- year of publication: 1974
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: insufficiently documented literature data, no details on study design and results
Data source
Reference
- Reference Type:
- publication
- Title:
- Industrial experience with 3,3'-dichlorobenzidine. An epidemiological study of a chemical manufacturing plant.
- Author:
- Gerarde HW, Gerarde DF
- Year:
- 1 974
- Bibliographic source:
- J. Occup. Med. 16: 322-344
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- in vivo eye irritation
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,3'-dichlorobenzidine
- EC Number:
- 202-109-0
- EC Name:
- 3,3'-dichlorobenzidine
- Cas Number:
- 91-94-1
- IUPAC Name:
- 3,3'-dichlorobiphenyl-4,4'-diamine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- no data
- Details on study design:
- - instillation into the conjunctival sac
Results and discussion
In vivo
Results
- Irritation parameter:
- other: discomfort or reaction
- Basis:
- other: no data
- Time point:
- other: no data
- Reversibility:
- not specified
- Remarks on result:
- other: caused no obvious discomfort and gave a negative reaction
- Other effects:
- The test item did not cause obvious discomfort or any other visible response.
Applicant's summary and conclusion
- Conclusions:
- The test item is not irritating to rabbit eyes under the conditions of this method.
- Executive summary:
The test item is not irritating to rabbit eyes under the conditions of this method.
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