Registration Dossier
Registration Dossier
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EC number: 210-323-0 | CAS number: 612-83-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- year of publication: 1974
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: insufficiently documented literature data; only LD50 value mentioned, no details on study design and results provided
Data source
Reference
- Reference Type:
- publication
- Title:
- Industrial experience with 3,3'-dichlorobenzidine. An epidemiological study of a chemical manufacturing plant.
- Author:
- Gerarde HW, Gerarde DF
- Year:
- 1 974
- Bibliographic source:
- J. Occup. Med. 16: 322-344
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- acute dermal toxicity
- GLP compliance:
- no
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- 3,3'-dichlorobenzidine
- EC Number:
- 202-109-0
- EC Name:
- 3,3'-dichlorobenzidine
- Cas Number:
- 91-94-1
- IUPAC Name:
- 3,3'-dichlorobiphenyl-4,4'-diamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - application on intact skin
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: MLD
- Effect level:
- > 8 000 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- The lethal dose of the test item after dermal application to rabbits is > 8000 mg/kg bw.
- Executive summary:
The lethal dose of the test item after dermal application to rabbits is > 8000 mg/kg bw.
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