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Description of key information

The effect of pH on the hydrolysis of 14C-dimethylhydantoin (DMH) was determined in a 30-day hydrolysis study. DMH did not significantly hydrolyze in the pH range of 5-9. DMH is stable in aqueous solutions at pH 5, 7 and 9 (t½ > 1 year (25°C)

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Additional information

Hydrolysis of radiolabelled DMH in aqueous media at 25°C was studied at pH 5, pH 9 and at pH 7 in two buffers: TRIS and HEPES. No hydrolysis was noted at pH 5 and 9. Minimal hydrolysis was observed at pH 7 giving half-lives of 3194 days (TRIS) and 1715 days (HEPES).