5,5-dimethylhydantoin

Dissociation constant

Administrative data

Endpoint:

dissociation constant

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study not performed to GLP or guideline but is otherwise well described

Data source

Reference

Reference Type:

publication

Title:

Studies in the physical chemistry of amino acids, peptides and related substances. IX The dissociation constants of some amino acid derivatives

Author:

Zeif M & Edsall JT

Year:

1937

Bibliographic source:

J. Amer.Chem.Soc. 59: 2245-2247

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The dissociation constants of some amino acid derivtaives which included 5,5-dimethylhydantoin were determined from e.m.f measurements on the cell H2/Acid-base solution/saturated KCl/HgCl/Hg

GLP compliance:

no

Remarks:

Pre-dates GLP

Test material

Test material information

Constituent 1

Reference substance name:

5,5-dimethylhydantoin

EC Number:

201-051-3

EC Name:

5,5-dimethylhydantoin

Cas Number:

77-71-4

Molecular formula:

C5H8N2O2

IUPAC Name:

5,5-dimethylimidazolidine-2,4-dione

Details on test material:

- Name of test material (as cited in study report): 5,5-dimethylhydantoin

Results and discussion

Dissociating properties:

yes

Dissociation constant

No.:

#1

pKa:

9.19

Temp.:

23.7 °C

Applicant's summary and conclusion

Conclusions:

5,5 dimethylhydantoin was estimated to have a dissociation constant of 9.19