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Physical & Chemical properties

Dissociation constant

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Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study not performed to GLP or guideline but is otherwise well described

Data source

Reference
Reference Type:
publication
Title:
Studies in the physical chemistry of amino acids, peptides and related substances. IX The dissociation constants of some amino acid derivatives
Author:
Zeif M & Edsall JT
Year:
1937
Bibliographic source:
J. Amer.Chem.Soc. 59: 2245-2247

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The dissociation constants of some amino acid derivtaives which included 5,5-dimethylhydantoin were determined from e.m.f measurements on the cell H2/Acid-base solution/saturated KCl/HgCl/Hg
GLP compliance:
no
Remarks:
Pre-dates GLP

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 5,5-dimethylhydantoin

Results and discussion

Dissociating properties:
yes
Dissosciation constant
No.:
#1
pKa:
9.19
Temp.:
23.7 °C

Applicant's summary and conclusion

Conclusions:
5,5 dimethylhydantoin was estimated to have a dissociation constant of 9.19