Registration Dossier
Registration Dossier
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EC number: 201-051-3 | CAS number: 77-71-4
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study not performed to GLP or guideline but is otherwise well described
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies in the physical chemistry of amino acids, peptides and related substances. IX The dissociation constants of some amino acid derivatives
- Author:
- Zeif M & Edsall JT
- Year:
- 1 937
- Bibliographic source:
- J. Amer.Chem.Soc. 59: 2245-2247
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The dissociation constants of some amino acid derivtaives which included 5,5-dimethylhydantoin were determined from e.m.f measurements on the cell H2/Acid-base solution/saturated KCl/HgCl/Hg
- GLP compliance:
- no
- Remarks:
- Pre-dates GLP
Test material
- Reference substance name:
- 5,5-dimethylhydantoin
- EC Number:
- 201-051-3
- EC Name:
- 5,5-dimethylhydantoin
- Cas Number:
- 77-71-4
- Molecular formula:
- C5H8N2O2
- IUPAC Name:
- 5,5-dimethylimidazolidine-2,4-dione
- Details on test material:
- - Name of test material (as cited in study report): 5,5-dimethylhydantoin
Constituent 1
Results and discussion
- Dissociating properties:
- yes
Dissociation constant
- No.:
- #1
- pKa:
- 9.19
- Temp.:
- 23.7 °C
Applicant's summary and conclusion
- Conclusions:
- 5,5 dimethylhydantoin was estimated to have a dissociation constant of 9.19
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