## Registration Dossier

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** EC number: 201-051-3 | CAS number: 77-71-4 **

- Life Cycle description
- Uses advised against

- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity

- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour

- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms

- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information

- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

## Vapour pressure

### Administrative data

- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Testing was conducted between 03 November 2009 and 17 November 2009.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.

### Data source

##### Reference

- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2010
- Report Date:
- 2010

### Materials and methods

##### Test guideline

- Qualifier:
- according to
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no

- GLP compliance:
- yes (incl. certificate)
- Remarks:
- Date of inspection: 15-09-2009 Date of Signature:26-11-2009
- Type of method:
- other: vapour pressure balance

#### Test material

##### Reference

- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- Sponsor's identification: DMH

Description: white crystalline solid

Batch number: N5439431

Date received: 24 February 2006

Storage conditions: room temperature in the dark

### Results and discussion

##### Vapour pressure

- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: The vapour pressure of the test material has been determined to be 3.8 x 10-4 Pa at 25ºC.

##### Transition / decomposition

- Transition / decomposition:
- no

#### Any other information on results incl. tables

## Results

Run1

Temperature (ºC) | Temperature (K) | Reciprocal Temperature (K | Mass Difference (µg) | Mass Difference (kg) | Vapour Pressure (Pa) | Log |

101 | 374.15 | 0.002672725 | 927.10 | 9.271E-07 | 1.287052322 | 0.109596202 |

102 | 375.15 | 0.002665600 | 996.02 | 9.960E-07 | 1.382730939 | 0.140737680 |

103 | 376.15 | 0.002658514 | 1095.47 | 1.095E-06 | 1.520793018 | 0.182070110 |

104 | 377.15 | 0.002651465 | 1187.39 | 1.187E-06 | 1.648401528 | 0.217063008 |

105 | 378.15 | 0.002644453 | 1316.91 | 1.317E-06 | 1.828208470 | 0.262025717 |

106 | 379.15 | 0.002637479 | 1413.14 | 1.413E-06 | 1.961800364 | 0.292654811 |

107 | 380.15 | 0.002630541 | 1540.30 | 1.540E-06 | 2.138331023 | 0.330074937 |

A plot of Log_{10}(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 1 gives the following statistical data using an unweighted least squares treatment.

Slope -5309.481

Standard deviation in slope 91.611

Intercept 14.297

Standard deviation in intercept 0.243

The results obtained indicate the following vapour pressure relationship:

Log_{10}(Vp (Pa)) = -5309.481/temp(K) + 14.297

The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -3.511.

Run 1 - Graph of Log_{10}Vapour Pressure vs Reciprocal Temperature (please see attached Run 1 to Run 4 Graphs of log_{10}Vapour Pressure vs Reciprocal Temperature)

Run 2

Temperature (ºC) | Temperature (K) | Reciprocal Temperature (K | Mass Difference (µg) | Mass Difference (kg) | Vapour Pressure (Pa) | Log |

101 | 374.15 | 0.002672725 | 927.73 | 9.277E-07 | 1.287926923 | 0.109891222 |

102 | 375.15 | 0.002665600 | 999.71 | 9.997E-07 | 1.387853604 | 0.142343658 |

103 | 376.15 | 0.002658514 | 1092.33 | 1.092E-06 | 1.516433893 | 0.180823483 |

104 | 377.15 | 0.002651465 | 1185.98 | 1.186E-06 | 1.646444086 | 0.216546987 |

105 | 378.15 | 0.002644453 | 1286.37 | 1.286E-06 | 1.785811126 | 0.251835524 |

106 | 379.15 | 0.002637479 | 1392.65 | 1.393E-06 | 1.933354995 | 0.286311605 |

107 | 380.15 | 0.002630541 | 1516.75 | 1.517E-06 | 2.105637589 | 0.323383625 |

A plot of Log_{10}(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 2 gives the following statistical data using an unweighted least squares treatment.

Slope -5076.768

Standard deviation in slope 36.058

Intercept 13.677

Standard deviation in intercept 0.096

The results obtained indicate the following vapour pressure relationship:

Log_{10}(Vp (Pa)) = -5076.768/temp(K) + 13.677

The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -3.350.

Run 2 - Graph of Log_{10}Vapour Pressure vs Reciprocal Temperature (please see attached Run 1 to Run 4 Graphs of log_{10}Vapour Pressure vs Reciprocal Temperature)

Run 3

Temperature (ºC) | Temperature (K) | Reciprocal Temperature (K | Mass Difference (µg) | Mass Difference (kg) | Vapour Pressure (Pa) | Log |

101 | 374.15 | 0.002672725 | 927.10 | 9.271E-07 | 1.287052322 | 0.109596202 |

102 | 375.15 | 0.002665600 | 1001.36 | 1.001E-06 | 1.390144227 | 0.143059860 |

103 | 376.15 | 0.002658514 | 1089.19 | 1.089E-06 | 1.512074769 | 0.179573267 |

104 | 377.15 | 0.002651465 | 1199.01 | 1.199E-06 | 1.664533065 | 0.221292426 |

105 | 378.15 | 0.002644453 | 1286.92 | 1.287E-06 | 1.786574667 | 0.252021172 |

106 | 379.15 | 0.002637479 | 1399.25 | 1.399E-06 | 1.942517486 | 0.288364937 |

107 | 380.15 | 0.002630541 | 1520.60 | 1.521E-06 | 2.110982376 | 0.324484607 |

A plot of Log_{10}(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 3 gives the following statistical data using an unweighted least squares treatment.

Slope -5119.079

Standard deviation in slope 60.228

Intercept 13.790

Standard deviation in intercept 0.160

The results obtained indicate the following vapour pressure relationship:

Log_{10}(Vp (Pa)) = -5119.079/temp(K) + 13.790

The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -3.379.

Run 3 - Graph of Log_{10}Vapour Pressure vs Reciprocal Temperature (please see attached Run 1 to Run 4 Graphs of log_{10}Vapour Pressure vs Reciprocal Temperature)

Run 4

Temperature (ºC) | Temperature (K) | Reciprocal Temperature (K | Mass Difference (µg) | Mass Difference (kg) | Vapour Pressure (Pa) | Log |

101 | 374.15 | 0.002672725 | 911.72 | 9.117E-07 | 1.265700941 | 0.102331103 |

102 | 375.15 | 0.002665600 | 996.73 | 9.967E-07 | 1.383716601 | 0.141047151 |

103 | 376.15 | 0.002658514 | 1077.18 | 1.077E-06 | 1.495401812 | 0.174757903 |

104 | 377.15 | 0.002651465 | 1182.21 | 1.182E-06 | 1.641210360 | 0.215164250 |

105 | 378.15 | 0.002644453 | 1273.66 | 1.274E-06 | 1.768166390 | 0.247523131 |

106 | 379.15 | 0.002637479 | 1393.75 | 1.394E-06 | 1.934882077 | 0.286654502 |

107 | 380.15 | 0.002630541 | 1496.27 | 1.496E-06 | 2.077206102 | 0.317479590 |

108 | 381.15 | 0.002623639 | 1652.39 | 1.652E-06 | 2.293940660 | 0.360582179 |

A plot of Log_{10}(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 4 gives the following statistical data using an unweighted least squares treatment.

Slope -5191.484

Standard deviation in slope 57.608

Intercept 13.978

Standard deviation in intercept 0.153

The results obtained indicate the following vapour pressure relationship:

Log_{10}(Vp (Pa)) = -5191.484/temp(K) + 13.978

The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -3.434.

Run 4- Graph of Log_{10}Vapour Pressure vs Reciprocal Temperature (please see attached Run 1 to Run 4 Graphs of log_{10}Vapour Pressure vs Reciprocal Temperature)

Summary of Results

Run | Log |

1 | -3.511 |

2 | -3.350 |

3 | -3.379 |

4 | -3.434 |

Mean | -3.418 |

Vapour Pressure | 3.8 x 10 |

### Applicant's summary and conclusion

- Conclusions:
- The vapour pressure of the test material has been determined to be 3.8 x 10-4 Pa at 25ºC.
- Executive summary:
## Method

The vapour pressure was determined using a vapour pressure balance withasurents being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25°C. Testing was conducted using Method A4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008.

## Procedure

The vapour pressure was determined using a vapour pressure balance. The temperature of the sample was controlled electronically. The mass and temperature readings were recorded automatically into a computer file.

A diagram of the cross-section of the vapour pressure balance is represented in attached Figure 4.1. After evacuating the system, opening the shutter above the sample oven causes the escaping vapour jet to be directed at the scale pan. The difference in mass readings with the orifice covered and uncovered is proportional to the vapour pressure at the given oven temperature.

A sequence of runs was started after a sample of test material had been under vacuum for approximately 68 hours. Temperature and pressure readings were taken between 100 and 110 ºC with a one hour dwell at 100 ºC between runs.**Summary of Results**Run

Log

_{10}[Vp(25ºC)]1

-3.511

2

-3.350

3

-3.379

4

-3.434

Mean

-3.418

Vapour Pressure

3.8 x 10

^{-4}Pa## Discussion

The unshaded points on the graphshave not been used when plotting the line. It is quite common for the first point of a run to be non linear as the system equilibrates after the dwell time.

## Conclusion

The vapour pressure of the test material has been determined to be 3.8 x 10^{-4 }Pa at 25ºC.

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