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EC number: 402-170-5
CAS number: 106359-91-5
C.I. REACTIVE YELLOW 174; GIALLO REATTIVO 174; JAUNE REACTIF 174; REAKTIV GELB 174
In a GLP-compliant micronucleus test, tested according to OECD guideline 474, 5 non-consanguinous OF-1 albino mice originating from an SPF colony per sex per treatment group were treated once by oral gavage with the test substance 5000 mg/kg bw dissolved in distilled water followed by a 20, 44, 68 hour exposure period. In a preliminary range finding study the concentration of 5000 mg/kg bw was chosen for the main-test. A positive control (Thio-TEPA) administered at a concentration of 20 mg/kg bw showed pronounced evidence of mutagenicity 44 h after administration. No mutagenic effect was observed in bone marrow smears taken 20, 44 and 68 h after administration of the test substance. Based on the study results, FAT 40226/C is not considered to be mutagenic in the micronucleus test.
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