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EC number: 402-170-5
CAS number: 106359-91-5
C.I. REACTIVE YELLOW 174; GIALLO REATTIVO 174; JAUNE REACTIF 174; REAKTIV GELB 174
In a GLP compliant dermal toxicity study, performed according to OECD guideline 402, Wistar rats (5/sex) were administered FAT 40224/C (2000 mg/kg bw). The test substance was dissolved in 4 % CMC in distilled water and applied on the skin with a syringe and covered with an occlusive dressing for 24 hours. The treated skin was washed after 24 h and a 14-day observation period followed. No mortality was observed during this period. The following symptoms were observed: Emaciation (females) and the application area was discolored. Discoloration of the treated skin was observed until termination of observation.
Based on the study results, the dermal median lethal dose (LD50) of the test substance was estimated to be: greater than 2000 mg/kg bw.
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