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EC number: 402-170-5
CAS number: 106359-91-5
C.I. REACTIVE YELLOW 174; GIALLO REATTIVO 174; JAUNE REACTIF 174; REAKTIV GELB 174
In a GLP-compliant eye irritation study, performed according to OECD guideline 405, the test substance (0.1 g) was placed in the conjunctival sac of the left eye of three New Zealand White rabbits. The eyes were examined for 72 hours. No acute toxic symptoms were observed in the animals during the test period, and no mortality occurred. In the area of application a red to yellow staining of the cornea, conjunctivae, sclera and lid hairs by pigment or coloring of the test article was observed. The body weight gain of all rabbits was similar. Due to the results obtained, no macroscopic organ examination was indicated. The test substance showed a primary irritation score of 0.0 when applied to the rabbit eye mucosa. A red to yellow staining of the cornea, conjunctivae, sclera and lid hairs of the treated eyes by pigment or coloring of the test article was observed. Cornea, iris, conjunctivae and chemosis scores were 0.0 during the whole observation period. No corrosion was observed at any of the measuring intervals. Under the conditions of this experiment, the test substance was found to be not irritating or corrosive.
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