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EC number: 242-272-5
CAS number: 18395-30-7
Dynasylan IBTMO (isobutyltrimethoxysilane) was tested in a traditional
Buehler skin sensitisation study, to GLP. Twenty Dunkin-Hartley
guinea-pigs were exposed to three separate induction phases on their
shaved left flanks. On Day 0 undiluted test substance was applied under
an occlusive patch for six hours. On Day 7 this process was repeated
with a 50% solution in corn oil. On Day 14 the process was repeated
again with a 50% solution in corn oil. After each application the skin
was monitored for reactions. Ten negative controls had patches with corn
oil only applied to their left flanks. On Day 28 both negative controls
and test animals had an occlusive patch of 50% test substance (in corn
oil) applied to their right flanks. After six hours the dressings were
removed and the areas wiped with corn oil. The skin was then assessed at
6, 24, 48 and 72 hours after administration. There were no skin
reactions in any of the test or negative control animals during the
challenge phase. The test substance was not a skin sensitiser.
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