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EC number: 242-272-5
CAS number: 18395-30-7
Trimethoxy(2-methylpropyl)silaneis part of a
group of organosilicon substances which hydrolyse in contact with
moisture and the toxicity of which is determined by a non-polar
mechanism of toxicity, and as such log Kow drives toxicity.
Substances in this group include alkoxy- and chloro- silanes having
secondary features that do not affect the toxicity of the substances.
These short-term aquatic toxicity studies used aqueous stock solutions
at concentration of 1000 to 1300 mg/l. At this concentration the silanol
hydrolysis product (which is formed in significant quantities over the
time-scale of the media preparation) can undergo condensation reactions
to give siloxane and siloxanol dimers, oligomers and polymers.
The stock solution used for the test medium was filtered and no
condensation products were observed and after filtration, the measured
DOC (dissolved oxygen concentrations) were within 20% of the nominal
concentration. Although polymerisation products such as oligomers could
still be present in the stock solution as filtration is limited to
solid, high viscous particles. It is considered reasonable to assume
that the concentrations at theLC50 or EC50 predominantly
represent the concentration of the test substance’s hydrolysis product
(and not the polymer).
At concentrations around 100 mg/l and below the polymerisation of this
substance is understood to be a reversible process. Therefore, while the
stock solution preparation was not carried out under ideal conditions
for this substance, the studies do indicate that the registered
substance is of low short-term toxicity to the tested organisms. In
addition, predicted values using a validated QSARs are in agreement with
the measured data.
ECOSAR predictions for the hydrolysis product
(2-methylpropyl)silanetriol confirm the low short-term toxicity to
aquatic organisms: EC50/LC50values 8500, 3100 and
410 mg/l for fish, invertebrates and algae respectively.
Methanol and is well characterised in the
public domain literature and are not hazardous at the concentrations
relevant to the studies; the short-term EC50and LC50values
for methanol are in excess of 1000 mg/l (OECD 2004a - SIDS for
methanol). Therefore, at the loading rates experienced in these tests it
is unlikely that the presence of either would significantly affect the
results of the tests.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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