Registration Dossier
Registration Dossier
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EC number: 242-272-5 | CAS number: 18395-30-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The key study is the only test available for skin sensitisation of trimethoxy(2 -methylpropyl)silane.
Migrated from Short description of key information:
In a skin sensitisation study (Hüls Prüfinstitut für Toxikologie, 1993d) conducted according to OECD 406 and to GLP, Dynasylan IBTMO (isobutyltrimethoxysilan) was not sensitising to the skin of Dunkin-Hartley guinea-pigs. There were no systemic effects reported.
Justification for selection of skin sensitisation endpoint:
The selected study is the only skin sensitisation study available for the registered substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Justification for classification or non-classification
Trimethoxy(2-methylpropyl)silane is not classified as a skin sensitiser according to Regulation (EC) No 1272/2008.
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