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EC number: 242-272-5
CAS number: 18395-30-7
In a skin irritation study conducted according to OECD 404 and to GLP (Hüls Prüfinstitut für Toxikologie, 1993b), Dynasylan IBTMO (trimethoxy(2-methylpropyl)silane) was irritating to the skin of small white Russian rabbits. There were no signs of systemic toxicity. In an eye irritation study conducted to a protocol similar to OECD 405, and to GLP (Hüls Prüfinstitut für Toxikologie, 1993c), Dynasylan IBTMO (isobutyltrimethoxysilan) was not irritating to the eyes of small white Russian rabbits. There were some minor signs of irritation involving the conjunctivae, that had reversed by 72 hours in two of the animals and by day 6 in one animal.
The key studies are the only data available for skin and eye irritation.
Based on the available in vivo data, trimethoxy(2
-methylpropyl)silane is classified as a 'Cat 2: Skin irritant' with the
hazard statement 'H315: Causes skin irritation' according to Regulation
(EC) No 1272/2008. There is no classification for eye irritation, based
on in vivo data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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