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EC number: 605-399-0
CAS number: 165252-70-0
Based on a skin reaction incidence of 0 % according to the CLP
regulation, dinotefuran is not a dermal sensitiser in the guinea pig,
and no EU classification is required .
No dermal irritation occurred at any concentration
of dinotefuran administered by topical application, up to 25% w/v.
Therefore, all dermal reactions were scored as zero. In the 4 animals
treated by intradermal injection, dinotefuran produced mild erythema
(grade 1) at 1% w/v, mild-moderate diffuse erythema (grade 1 - 2)
reactions at 5% w/v and moderate-marked erythema (grade 2 - 3) at 10 and
15% w/v (Table 7.4.1).
There were no treatment-related clinical signs or
adverse effects on body weight with the exception of one animal in the
test group that appeared thin from day 20.
None of the test and control group animals
exhibited a dermal response to the challenge application of the test or
control articles either 24 or 48 hours after patch removal. Therefore,
all dermal reaction scores were zero.
Table 7.4.1: Individual dermal reaction scores
in the irritation screening study - intradermal injection
Dermal reaction score at:
For dinotefuran, oral LD50 values of 2804, 2000 and 2450 mg/kg are
identified in rats for
males, females and for the sexes combined, respectively. Similar values
were identified in
mice. In oral gavage rabbit developmental toxicity studies, clinical
signs of toxicity were
observed on the first day of dosing at 300 mg/kg and above; the NOAEL
for acute effects in
NZW rabbits is 125 mg/kg. The rat dermal LD50 value is estimated to be
>2000 mg/kg and the
4 h inhalation LC50 value is estimated be > 4.09 mg/L in males and
females. These data do
not support classification of dinotefuran for acute toxicity.
Dinotefuran is not a skin, eye or
respiratory tract irritant nor a skin sensitiser.
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