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EC number: 605-399-0
CAS number: 165252-70-0
No dermal irritation occurred at any concentration
of dinotefuran administered by topical application, up to 25% w/v.
Therefore, all dermal reactions were scored as zero. In the 4 animals
treated by intradermal injection, dinotefuran produced mild erythema
(grade 1) at 1% w/v, mild-moderate diffuse erythema (grade 1 - 2)
reactions at 5% w/v and moderate-marked erythema (grade 2 - 3) at 10 and
15% w/v (Table 7.4.1).
There were no treatment-related clinical signs or
adverse effects on body weight with the exception of one animal in the
test group that appeared thin from day 20.
None of the test and control group animals
exhibited a dermal response to the challenge application of the test or
control articles either 24 or 48 hours after patch removal. Therefore,
all dermal reaction scores were zero.
Table 7.4.1: Individual dermal reaction scores
in the irritation screening study - intradermal injection
Dermal reaction score at:
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