Registration Dossier

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14/09/1999 - 15/03/2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP, Guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
39.83 g/L
Temp.:
20 °C
pH:
6.98

Summary of dinotefuran water solubility data

Sampling interval

Time equilibrated at 20ºC (hr)

Temperature (ºC)

Dinotefuran g/L

% difference

pH reading

Trial

Date

Time at 30ºC (hr)

1

18-Jan

67.57

28.17

19.7

39.37

 

6.99

2

19-Jan

91.57

26.75

19.7

39.80

1.1

6.96

3

20-Jan

116.48

24.42

19.7

40.32

1.3

6.98

 

 

 

Average

19.7

39.83

 

6.98

 

 

 

Std Dev

0.00

0.48

0.02

 

 

 

% RSD

0.0

1.2

0.2

Conclusions:
Interpretation of results : very soluble (> 10000 mg/L)
Solubility of dinotefuran in unbuffered water is 39.83 g/L (pH 6.98) at 20°C.
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21/08/1995 - 29/07/1998
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP, Guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Water solubility:
39 g/L
Temp.:
10 °C
Remarks on result:
other: solubility in purified water
Water solubility:
54.3 g/L
Temp.:
20 °C
Remarks on result:
other: solubility in purified water
Water solubility:
89.7 g/L
Temp.:
30 °C
Remarks on result:
other: solubility in purified water
Water solubility:
52.3 g/L
Temp.:
20 °C
pH:
5
Remarks on result:
other: pH 5 buffer solution
Water solubility:
54.5 g/L
Temp.:
20 °C
pH:
7
Remarks on result:
other: pH 7 buffer solution
Water solubility:
51.2 g/L
Temp.:
20 °C
pH:
9
Remarks on result:
other: pH 9 buffer solution

Measurements of water solubility

Measurements of water solubility at 10ºC

Sample

Time (days)

Concentration (g/L)

Mean concentration (g/L)

pH

Held at 20ºC

Equilibrated at 10ºC

1A, 1B

1

1

56.9, 57.9

57.4

8.12, 8.12

2A, 2B

2

1

59.7, 53.4

56.6

7.88, 7.89

3A, 3B

3

1

49.3, 44.5

46.9

7.82, 7.83

4A, 4B

7

1

36.0, 39.4

37.7

7.83, 7.77

5A, 5B

8

1

39.6, 41.0

40.3

7.66, 7.75

Measurements of water solubility at 20ºC

Sample

Time (days)

Concentration (g/L)

Mean concentration (g/L)

pH

Held at 20ºC

Equilibrated at 10ºC

1A, 1B

1

1

54.2, 55.1

54.6

7.76, 7.84

2A, 2B

2

1

53.5, 56.2

54.8

7.75, 7.75

3A, 3B

3

1

54.5, 52.5

53.5

7.79, 7.79

Measurements of water solubility at 30ºC

Sample

Time (days)

Concentration (g/L)

Mean concentration (g/L)

pH

Held at 40ºC

Equilibrated at 30ºC

1A, 1B

1

1

89.0, 88.9

88.9

7.89, 7.88

2A, 2B

2

1

87.4, 87.8

87.6

7.80, 7.82

3A, 3B

3

1

91.2, 94.1

92.7

7.92, 8.10

Measurements of pH 5.0 buffer solubility at 20ºC

Sample

Time (days)

Concentration (g/L)

Mean concentration (g/L)

pH

Held at 30ºC

Equilibrated at 20ºC

1A, 1B

1

1

53.3, 53.3

53.3

5.09, 5.10

2A, 2B

2

1

51.7, 52.4

52.1

5.06, 5.04

3A, 3B

3

1

50.7, 52.2

51.5

5.05, 5.14

Measurements of pH 7.0 buffer solubility at 20ºC

Sample

Time (days)

Concentration (g/L)

Mean concentration (g/L)

pH

Held at 30ºC

Equilibrated at 20ºC

1A, 1B

1

1

56.1, 54.0

55.1

7.05, 7.02

2A, 2B

2

1

54.0, 54.5

54.3

7.11, 7.08

3A, 3B

3

1

53.9, 54.4

54.1

7.12, 7.06

Measurements of pH 9.0 buffer solubility at 20ºC

Sample

Time (days)

Concentration (g/L)

Mean concentration (g/L)

pH

Held at 30ºC

Equilibrated at 20ºC

1A, 1B

1

1

54.0, 52.4

53.2

9.01, 9.01

2A, 2B

2

1

51.3, 49.2

50.2

9.03, 9.03

3A, 3B

3

1

50.6, 49.5

50.1

9.05, 9.04

 

Conclusions:
very soluble (> 10000 mg/L)
Solubility of dinotefuran in water is 54.3 ± 1.3 g/L at 20°C.

Description of key information

Key value for chemical safety assessment

Water solubility:
39.83 g/L
at the temperature of:
20 °C

Additional information