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Physical & Chemical properties

Partition coefficient

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Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14/09/1999 - 15/03/2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP, Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report Date:
2000

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
Deviations:
no
GLP compliance:
yes
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: solid

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
-0.549
Temp.:
25 °C
Remarks on result:
other: Pow = 0.283
Details on results:
See tables below

Any other information on results incl. tables

Partition coefficient of data of dinotefuran (<0.01M)

Oct/Water ratio

Volume of Octanol (mL)

Volume of Water (mL)

Total µg dinotefuran present

µg dinotefuran recovered from Octanol

µg dinotefuran recovered from Water

Total µg dinotefuran recovered

Conc. Analysed in Octanol Phase (µg/mL)

Conc. Analysed in Water Phase (µg/mL)

Kow

Log Kow

2:1

20

10

20088

7413

13101

20514

370.64

1310.13

0.283

-0.548

1:1

20

20

20088

4584

15915

20499

229.21

795.73

0.288

-0.541

0.5:1

10

20

10044

1336

8447

9783

133.58

422.35

0.316

-0.500

 

 

 

 

 

 

 

 

Average

0.296

-0.530

 

 

 

 

 

 

 

 

Std Dev

0.02

-0.03

 

 

 

 

 

 

 

 

% RSD

6.1

-4.9

 

Partition coefficient of data of dinotefuran (<0.001M)

Oct/Water ratio

Volume of Octanol (mL)

Volume of Water (mL)

Total µg dinotefuran present

µg dinotefuran recovered from Octanol

µg dinotefuran recovered from Water

Total µg dinotefuran recovered

Conc. Analysed in Octanol Phase (µg/mL)

Conc. Analysed in Water Phase (µg/mL)

Kow

Log Kow

2:1

20

10

2009

740

1283

2023

36.98

128.29

0.288

-0.540

1:1

20

20

2009

440

1582

2022

22.01

79.11

0.278

-0.556

0.5:1

10

20

1004

113

880

994

11.32

44.02

0.257

-0.590

 

 

 

 

 

 

 

 

Average

0.275

-0.562

 

 

 

 

 

 

 

 

Std Dev

0.02

0.03

 

 

 

 

 

 

 

 

% RSD

5.8

-4.5

Applicant's summary and conclusion

Conclusions:
The partition coefficient of dinotefuran is: log Pow = - 0.549 at 25°C (i.e. Pow = 0.283)