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EC number: 203-777-6
CAS number: 110-54-3
One human epidemiological study was identified for C6 aliphatics, high n-hexane (Wang, 1986; Klimisch score =2).
In a key
epidemiological study researchers evaluated a group of 59 press proofing
workers from 16 factories who were employed for at least 2 months (Wang,
1986; Klimisch score =2). All but four of these workers had regular
contact with solvents in the process of cleaning the rollers. Two
exposure measures using personal air samplers were taken in 14 of the 16
factories. Referent neurological data was also collected from workers
and healthy individuals. MCVs were also collected from workers exposed
examination identified 15 workers with polyneuropathy and two
ashymptomatic workers with abnormal MCVs. All but one of the workers
were employed in factories that used solvents with n-hexane
concentrations in excess of 50%.
No association was
found with length of employment, statistically significant associations
existed between frequency of polyneuropathy and abnormal MCV and
n-hexane concentration in the cleaning solvents and between the
frequency of polyneuropathy and n-hexane air concentrations. However, a
significant reduction in the MCV was found among workers exposed to air
concentrations less than 25 ppm, a result that the authors considered to
be related to the prolonged exposure due to overtime work.
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