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Hydrolysis is a reaction in which a water molecule or hydroxide ion substitutes for another atom or group of atoms present in a chemical resulting in a structural change of that chemical. Potentially hydrolyzable groups include alkyl halides, amides, carbamates, carboxylic acid esters and lactones, epoxides, phosphate esters, and sulfonic acid esters (Neely, 1985). The lack of a suitable leaving group renders compounds resistant to hydrolysis.

Isohexane consists entirely of carbon and hydrogen and do not contain hydrolysable groups. As such, they have a very low potential to hydrolyze. Therefore, this degradative process will not contribute to their removal from the environment.


An OECD 301F Manometric Respirometry test was conducted using C6-C7, n-alkanes, isoalkanes, cyclics C6 aliphatics (Shell 1997). The test substance was 98% degraded at the end of 28 days, and 83% degraded at the end of the 10 -day window. This is read across to isohexane. This is supported by QSAR predictions that isohexane is readily biodegradable.