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EC number: 203-777-6
CAS number: 110-54-3
Governa et al. (1987) investigated the
correlation between electrographic changes indicative of polyneuropathy
and urinary excretion of metabolites indicative of exposure to n-hexane.
Forty workers were randomly chosen from four small shoe factories. All
workers handled a type of glue or solvent that contained over 50%
n-hexane without protective equipment for about 7 hours/day. All
subjects exhibited no more than mild or nonspecific symptoms of
polyneuropathy and were free of other known risk factors for nervous
system impairment. A urine sample was collected at the end of a shift,
and then a neurophysiological examination (MCV, SCV, and associated
distal latencies [DL]) was carried out the following day. Reference
values were obtained from 41 unexposed individuals. The urinary
concentrations n-hexane metabolites were measured in 40 workers, but
only those for two of the five n-hexane metabolites were above minimum
detection limits (MDLs): 2,5-hexanedione (mean, 6.80 mg/L) and
(valerolactone (mean, 3.31 mg/L). A statistically significant
dose-response relationship for the electroneuromyography (ENM) scores
was found for 2,5 -hexanedione and valerolactone. A threshold value of
7.5 mg/L was closely related to the incidence of abnormalities. Some
variation from the relationship was apparent because three workers with
lower concentrations of 2.5 -hexanedione (3.0, 3.3, and 4.5 mg/L)
displayed ENM changes.
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