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EC number: 203-777-6
CAS number: 110-54-3
Study authors evaluated a group of 59 press
proofing workers from 16 factories who were employed for at least 2
months. All but four of these workers had regular contact with solvents
in the process of cleaning the rollers. Two exposure measures using
personal air samplers were taken in 14 of the 16 factories. Referent
neurological data was also collected from workers and healthy
individuals. MCVs were also collected from workers exposed to n-hexane.
Samples of the bulk cleaning solvents were
found to contain n-hexane at concentrations ranging from 10–65%.
Referent neurological data were collected from 150 healthy individuals
(50 persons from three age groups, 10–35, 36–50, and 51–80 years, sex
not stated). MCVs among workers exposed to n-hexane were consistently
lower than among controls. The results of the neurological examination
identified 15 workers with polyneuropathy and two asymptomatic workers
with abnormal MCVs. All but one of these workers were employed in
factories that used solvents with n-hexane concentrations in excess of
While no association was found with length
of employment, statistically significant associations existed between
frequency of polyneuropathy and abnormal MCV and n-hexane concentration
in the cleaning solvents and between the frequency of polyneuropathy and
n-hexane air concentrations. Among the workers with polyneuropathy, a
high percentage worked in factories with n-hexane air concentrations
greater than 100 ppm. However, a significant reduction in the MCV was
found among workers exposed to air concentrations less than 25 ppm, a
result that the authors considered to be related to the prolonged
exposure due to overtime work.
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