Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

In a key sensitisation study (Basketter et al., 2000; Klimisch score=2), a local lymph node assay (LLNA) was done to determine the concentration of hexane that would be expected to cause sensitisation in humans. Results of previous LLNA experiments were used to calculate the EC3 value, the concentration at which the test substance would produce a 3 -fold increase in the proliferative activity of lymph nodes in the LLNA test. The 3 -fold increase is considered a positive response for sensitization in the LLNA test. The EC3 value for hexane was determined to be > 100% concentration. The test substance is therefore not sensitising.


Migrated from Short description of key information:
One key study (Basketter et al., 2000; Klimisch score=2) was identified for skin sensitisation.

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
No data for respiratory sensitisation were identified.

Justification for classification or non-classification

n-Hexane is not classified for sensitisation.